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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
12.12
Human Site:
S231
Identified Species:
24.24
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
S231
A
P
M
E
R
L
A
S
Y
G
S
S
K
A
A
Chimpanzee
Pan troglodytes
XP_511130
387
42727
S231
A
P
M
E
R
L
A
S
Y
G
S
S
K
A
A
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
S230
A
P
M
A
K
L
A
S
Y
G
S
S
K
A
A
Dog
Lupus familis
XP_546810
382
41989
A232
V
P
M
E
K
L
A
A
Y
S
S
S
K
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
A232
V
P
L
Q
M
T
S
A
Y
A
A
T
K
A
A
Rat
Rattus norvegicus
Q62730
381
41949
A232
I
P
F
Q
M
V
A
A
Y
A
S
T
K
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
A223
T
P
F
S
Y
L
C
A
Y
G
S
S
K
A
A
Chicken
Gallus gallus
Q5ZJZ5
339
38218
G197
S
S
M
M
G
R
M
G
S
P
A
R
S
P
Y
Frog
Xenopus laevis
NP_001086062
388
43271
A235
H
S
F
P
Y
L
A
A
Y
G
S
S
K
A
A
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
S220
H
P
F
P
C
L
A
S
Y
G
A
S
K
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
R183
L
L
P
S
M
V
K
R
G
S
G
H
I
C
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
A231
M
P
Y
P
C
L
A
A
Y
G
T
S
K
A
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
73.3
N.A.
33.3
46.6
N.A.
60
6.6
60
66.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
86.6
N.A.
73.3
73.3
N.A.
66.6
20
66.6
73.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
60
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
0
9
0
0
67
50
0
17
25
0
0
84
84
% A
% Cys:
0
0
0
0
17
0
9
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
25
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
9
0
0
9
9
59
9
0
0
0
0
% G
% His:
17
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
17
0
9
0
0
0
0
0
84
0
0
% K
% Leu:
9
9
9
0
0
67
0
0
0
0
0
0
0
0
0
% L
% Met:
9
0
42
9
25
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
75
9
25
0
0
0
0
0
9
0
0
0
9
0
% P
% Gln:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
17
9
0
9
0
0
0
9
0
0
0
% R
% Ser:
9
17
0
17
0
0
9
34
9
17
59
67
9
0
0
% S
% Thr:
9
0
0
0
0
9
0
0
0
0
9
17
0
0
0
% T
% Val:
17
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
17
0
0
0
84
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _